Evaluation of New Antituberculosis Drugs in Mouse Models
نویسندگان
چکیده
منابع مشابه
Evaluation of new antituberculosis drugs in mouse models.
In the study of the activity of PA-824 in mice performed by Nuermberger et al. (3), the authors observe that “regimens were not statistically different on the primary outcome” and propose that new studies using shorter regimens are needed “to determine conclusively whether substitution of PA-824 for isoniazid has the potential” to shorten treatment in humans. We agree but have concerns about th...
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15 صفحه اولAntituberculosis drugs and hepatotoxicity.
Isoniazid, pyrazinamide and rifampicin have hepatotoxic potential, and can lead to such reactions during antituberculosis chemotherapy. Most of the hepatotoxic reactions are dose-related; some are, however, caused by drug hypersensitivity. The immunogenetics of antituberculosis drug-induced hepatotoxicity, especially inclusive of acetylaor phenotype polymorphism, have been increasingly unravell...
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5. Mandell DL, Wald ER, Michaels MG, Dohar JE. Management of nontuberculous mycobacterial cervical lymphadenitis. Arch Otolaryngol Head Neck Surg 2003; 129:341–4. 6. Gerrits JA, Wolfs TF, Geelen SP. Three toddlers with a swelling in the neck [in Dutch]. Ned Tijdschr Geneeskd 2003; 147:225–9. 7. Lindeboom JA, Kuijper EJ, Bruijnesteijn van Coppenraet ES, R. Lindeboom, Prins JM. Surgical excision ...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2007
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01246-06